Diagnostic accuracy of f18-fluorodeoxyglucose positron emission tomography-computed tomography in the evaluation of carcinoma of unknown primary: A single-center study

Background: The term carcinoma of unknown primary (CUP) is not a single disease entity that it can be explicated as the recognition metastasized tumor, in which origin malignancy from an organ or site remains occult. refers to clinical disorder revolves around and represents diversified metastatic tumor group, for whom diagnostic investigations are unable pinpoint comprising extensive radiological techniques, invasive endoscopic procedures, histopathology, many fail diagnose site. Aims Objectives: study was conducted ascertain accuracy fluorine-18 labeled fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) evaluation CUP. secondary objective identify rate malignancies localized on 18F-FDG PET-CT presents CUP local settings. Materials Methods: prospective cross-sectional included patients with who underwent scans between October 2021 February 2022. confirmed through biopsy histology. False-negative false-positive were ascertained and/or follow-up 6 months. Results: Of total 63 patients, 57.1% male, while 42.9% female mean age 56.27 years. overall detection (PT) 88.8%. Abnormal sites indicative malignant correctly detected 79.36% truly positive proven biopsy. scan 4.76%, though other follow-up, 6.36% had true negative 9.52% showed results scan. In this study, calculated identified 85.7%, sensitivity 94%, specificity 40%, predictive value 89.2%, 57.1%. Conclusion: demonstrated high ascertaining PT our population.